Journal Club: RP-UHPLC-MS versus peptide mapping for antibody characterization
Introduction and background
Monoclonal antibodies (mABs) are immunoglobulin molecules that bind to the same epitope and have a variety of applications in medicine and healthcare (e.g. as drugs). Although therapeutic mABs are extremely favorable due to their specificity, they are heterogeneous due to their manufacturing process and hence provide a challenge for characterization.